Publications

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

Bahar Bazeli, Alexander V Shkumatov, Stephan Schenck, Jean-Christophe Vanherck, Annelies Janssens, Stéphane A H Spieser, Damien Marchand, Robbe Roelens, Patrick Chaltin, Arnaud Marchand, Joris Vriens, Thomas Voets@, Janine D Brunner@. Nat Commun. 2026 Apr 1. doi: 10.1038/s41467-026-71226-0. Epub ahead of print. PMID: 41922314.

Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer

Liu M, Vandekeere A, Liu XZ, Schenck S, Fernández-García J, Tricot T, Peng-Winkler Y, Demicco M, Broekaert D, Vermeire I, Theile J, Zels G, Pabba A, Desmedt C, Brunner JD, Altea-Manzano P, Fendt SM@. Nat Cell Biol. 2026 Mar 13. doi: 10.1038/s41556-026-01913-z. Epub ahead of print. PMID: 41826695.

MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony

Gangadhar Eluru, Steven De Gieter, Stephan Schenck, Annelore Stroobants, Binesh Shrestha, Paul Erbel, Janine D. Brunner, Rouslan G. Efremov@. Nature Methods (2025) https://doi.org/10.1038/s41592-025-02894-x

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

Bahar Bazeli, Alexander V Shkumatov, Stephan Schenck, Jean-Christophe Vanherck, Annelies Janssens, Robbe Roelens, Joris Vriens, Thomas Voets@, Janine D Brunner@. bioRxiv. 2025.08.27.671268; doi: https://doi.org/10.1101/2025.08.27.671268

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams

Stephan Schenck, Toon Laeremans, Jan Steyaert, Janine D. Brunner@. Nature Communications 2025 May 5;16(1):4172. doi: 10.1038/s41467-025-59545-0. PMID: 40325068; PMCID: PMC12053756.

MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony

Gangadhar Eluru, Steven De Gieter, Stephan Schenck, Annelore Stroobants, Binesh Shrestha, Paul Erbel, Janine D. Brunner, Rouslan G. Efremov@. bioRxiv. 2025.01.10.632437; doi: https://doi.org/10.1101/2025.01.10.632437

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling. 

Danielle M. Clancy@, Alba Sanz-Sanjuan, Elisabeth Gilis, Peter Tougaard, Imke Velghe, Yana Van Droogenbroeck, Jan Felix, Yehudi Bloch, Álvaro Furones Cuadrado, Romain Merceron, Stephan Schenck, Peter Vandenabeele, Janine D. Brunner, Tom Taghon, Dirk Elewaut, Savvas N. Savvides@. bioRxiv. 2025.02.16.638521; doi: https://doi.org/10.1101/2025.02.16.638521

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Mathieu Botte, Dongchun Ni, Stephan Schenck, Iwan Zimmermann, Mohamed Chami, Nicolas Bocquet, Pascal Egloff, Denis Bucher, Matilde Trabuco, Robert K. Y. Cheng, Janine D. Brunner, Markus A. Seeger, Henning Stahlberg & Michael Hennig@. Nature Communications 13, 1826 (2022). https://doi.org/10.1038/s41467-022-29459-2.

Structural basis for ion selectivity in TMEM175 K+ channels

Brunner JD@, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, Maier T, Schenck S@. Elife. 2020 Apr 8;9:e53683. doi: 10.7554/eLife.53683. PMID: 32267231; PMCID: PMC7176437.

Production and Application of Nanobodies for Membrane Protein Structural Biology.

Brunner JD@, Schenck S. Methods Mol Biol. 2020;2127:167-184. doi: 10.1007/978-1-0716-0373-4_12. PMID: 32112322.

Preparation of Proteoliposomes with Purified TMEM16 Protein for Accurate Measures of Lipid Scramblase Activity

Brunner JD@, Schenck S. Methods Mol Biol. 2019;1949:181-199. doi: 10.1007/978-1-4939-9136-5_14. PMID: 30790257.

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.

Paulino C, Neldner Y, Lam AK, Kalienkova V, Brunner JD, Schenck S, Dutzler R@. Elife. 2017 May 31;6:e26232. doi: 10.7554/eLife.26232. PMID: 28561733; PMCID: PMC5470873.

Structural basis for phospholipid scrambling in the TMEM16 family

Brunner JD, Schenck S, Dutzler R@. Curr Opin Struct Biol. 2016 Aug;39:61-70. doi: 10.1016/j.sbi.2016.05.020. Epub 2016 Jun 10. PMID: 27295354.

X-ray structure of a calcium-activated TMEM16 lipid scramblase

Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R@. Nature. 2014 Dec 11;516(7530):207-12. doi: 10.1038/nature13984. Epub 2014 Nov 12. PMID: 25383531.

Calcium-activated proteins visualized - News and views by Matt Whorton