VIB-VUB Center for Structural Biology Brunner Lab

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Structure and Function of Membrane Proteins

Membrane proteins are mediators of essential processes in the cell such as solute transport, electrical excitability and signaling. Atomistic insight into the architecture of membrane proteins, their conformational breadth and precise functioning is essential in fundamental research. Since membrane proteins are major targets of small molecule drugs these insights are also necessary for the treatment of life-threatening diseases. In the Brunner lab we study the structure and function of membrane proteins, with a particular emphasis on lipid biology and ion channels in membrane transport.

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Janine Brunner

Since 2020      VIB group leader at VIB-VUB Center for Structural Biology in Brussels, Belgium

2018 - 2019     Postdoc, Paul Scherrer Institute (ETH), Switzerland

2017                 Postdoc, Biozentrum (University of Basel), Switzerland

2015 - 2016     Postdoc, University of Zürich, Switzerland

2010 - 2015     PhD, University of Zürich, Switzerland

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Latest publications

LptDE with Pro-Macrobodies

Mathieu Botte, Dongchun Ni, Stephan Schenck, Iwan Zimmermann, Mohamed Chami, Nicolas Bocquet, Pascal Egloff, Denis Bucher, Matilde Trabuco, Robert K. Y. Cheng, Janine D. Brunner, Markus A. Seeger, Henning Stahlberg & Michael Hennig. Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nature Communications 13, 1826 (2022). https://www.nature.com/articles/s41467-022-29459-2

tmem175-full

Brunner JD, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, Maier T, Schenck S. Structural basis for ion selectivity in TMEM175 K+ channels. Elife. 2020 Apr 8;9:e53683. doi: 10.7554/eLife.53683. PMID: 32267231; PMCID: PMC7176437. https://elifesciences.org/articles/53683v1